For research use only. Not for therapeutic Use.
Magnolol（Cat No.:I003932）is a bioactive compound extracted from the bark of Magnolia species, known for its potent anti-inflammatory, antioxidant, and antimicrobial properties. It has shown promise in supporting cardiovascular health by modulating lipid profiles and reducing oxidative stress. Additionally, magnolol exhibits neuroprotective effects and is studied for its potential in alleviating anxiety and depression by interacting with GABA receptors. Its wide-ranging pharmacological activities make it a valuable natural agent in research exploring treatments for inflammatory conditions, neurodegenerative diseases, and metabolic disorders, highlighting its therapeutic potential in integrative medicine.
| Catalog Number | I003932 |
| CAS Number | 528-43-8 |
| Synonyms | NSC 293099 |
| Molecular Formula | C18H18O2 |
| Purity | ≥95% |
| Solubility | DMSO: 37 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol |
| InChI | InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2 |
| InChIKey | VVOAZFWZEDHOOU-UHFFFAOYSA-N |
| SMILES | C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O |
| Reference | </br>1:Chemoenzymatic Synthesis and α-Glucosidase Inhibitory Activity of Dimeric Neolignans Inspired by Magnolol. Pulvirenti L, Muccilli V, Cardullo N, Spatafora C, Tringali C.J Nat Prod. 2017 May 12. doi: 10.1021/acs.jnatprod.7b00250. [Epub ahead of print] PMID: 28497968 </br>2:Effect of magnolol on cerebral injury and blood brain barrier dysfunction induced by ischemia-reperfusion in vivo and in vitro. Liu X, Chen X, Zhu Y, Wang K, Wang Y.Metab Brain Dis. 2017 Apr 4. doi: 10.1007/s11011-017-0004-6. [Epub ahead of print] PMID: 28378105 </br>3:Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson/’s disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging. Weng CC, Chen ZA, Chao KT, Ee TW, Lin KJ, Chan MH, Hsiao IT, Yen TC, Kung MP, Hsu CH, Wey SP.PLoS One. 2017 Mar 3;12(3):e0173503. doi: 10.1371/journal.pone.0173503. eCollection 2017. PMID: 28257461 Free PMC Article</br>4:Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells. Chen X, Hu Y, Shan L, Yu X, Hao K, Wang GX.Fish Shellfish Immunol. 2017 Apr;63:245-254. doi: 10.1016/j.fsi.2017.02.020. Epub 2017 Feb 20. PMID: 28232195 </br>5:Magnolol Attenuates Concanavalin A-induced Hepatic Fibrosis, Inhibits CD4<sup>+</sup> T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling. Zhang H, Ju B, Zhang X, Zhu Y, Nie Y, Xu Y, Lei Q.Basic Clin Pharmacol Toxicol. 2017 Jun;120(6):560-570. doi: 10.1111/bcpt.12749. Epub 2017 Mar 7. PMID: 28032440 </br>6:Magnolol Enhances Hippocampal Neurogenesis and Exerts Antidepressant-Like Effects in Olfactory Bulbectomized Mice. Matsui N, Akae H, Hirashima N, Kido Y, Tanabe S, Koseki M, Fukuyama Y, Akagi M.Phytother Res. 2016 Nov;30(11):1856-1861. doi: 10.1002/ptr.5695. Epub 2016 Aug 11. PMID: 27510271 </br>7:Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats. Tsai T, Kao CY, Chou CL, Liu LC, Chou TC.J Microencapsul. 2016 Aug;33(5):401-11. doi: 10.1080/02652048.2016.1202344. Epub 2016 Jun 29. PMID: 27357644 </br>8:Magnolol pretreatment attenuates heat stress-induced IEC-6 cell injury. Mei C, He SS, Yin P, Xu L, Shi YR, Yu XH, Lyu A, Liu FH, Jiang LS.J Zhejiang Univ Sci B. 2016 Jun;17(6):413-24. doi: 10.1631/jzus.B1500261. PMID: 27256675 Free PMC Article</br>9:Methylation and Esterification of Magnolol for Ameliorating Cutaneous Targeting and Therapeutic Index by Topical Application. Lin CF, Hung CF, Aljuffali IA, Huang YL, Liao WC, Fang JY.Pharm Res. 2016 Sep;33(9):2152-67. doi: 10.1007/s11095-016-1953-x. Epub 2016 May 27. PMID: 27233503 </br>10:[Effect of Magnolol on Proliferation and Apoptosis of HL-60 Cells and Its Molecular Mechanism]. Fang K, Yuan XF, Liao Q, Zhang ZY, Song GH, Guo Q, Ren X, Jiang GS.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr;24(2):388-93. doi: 10.7534/j.issn.1009-2137.2016.02.015. Chinese. PMID: 27150997 |
