Mal-amido-(CH2COOH)2

• CAT Number: I017661
• CAS Number: 207613-14-7
• Molecular Formula: C11H12N2O7
• Molecular Weight: 284.22
• Purity: ≥95%
• Synonyms: 2-[carboxymethyl-[3-(2,5-dioxopyrrol-1-yl)propanoyl]amino]acetic acid
• InChI: InChI=1S/C11H12N2O7/c14-7(12(5-10(17)18)6-11(19)20)3-4-13-8(15)1-2-9(13)16/h1-2H,3-6H2,(H,17,18)(H,19,20)
• InChIKey: WGKBLBPWMDGTDE-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCC(=O)N(CC(=O)O)CC(=O)O

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].
Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].
ADC Linker

Reference

[1]. Dubowchik GM, et al. Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages.Bioorg Med Chem Lett. 2002 Jun 3;12(11):1529-32.
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