Mal-amido-PEG2-TFP ester

• CAT Number: I017023
• CAS Number: 1431291-44-9
• Molecular Formula: C₂₀H₂₀F₄N₂O₇
• Molecular Weight: 476.38
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: (2,3,5,6-tetrafluorophenyl) 3-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C20H20F4N2O7/c21-12-11-13(22)19(24)20(18(12)23)33-17(30)4-7-31-9-10-32-8-5-25-14(27)3-6-26-15(28)1-2-16(26)29/h1-2,11H,3-10H2,(H,25,27)
• InChIKey: HHXSYLTYQVHXMA-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCC(=O)NCCOCCOCCC(=O)OC2=C(C(=CC(=C2F)F)F)F

Mal-amido-PEG2-TFP ester（Cat No.:I017023）is a compound used in bioconjugation and drug delivery applications. It consists of a maleimide group (Mal) for selective conjugation to thiol groups on proteins or peptides, an amido linkage, and a polyethylene glycol (PEG2) chain with two ethylene glycol units that enhance water solubility and stability. The TFP ester (trifluoromethylphenyl ester) is a reactive group used to facilitate the formation of amide bonds with amine-containing molecules, allowing for efficient conjugation in biochemical reactions. This molecule is often employed in the development of targeted therapies, antibody-drug conjugates, and diagnostic agents.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.