For research use only. Not for therapeutic Use.
Mal-amido-PEG6-NHS ester(CAT: I016731) is a compound used in bioconjugation and chemical modification strategies. It consists of a maleimide (Mal) functional group, a PEG (polyethylene glycol) chain with six ethylene glycol units, and an N-hydroxysuccinimide (NHS) ester group. The maleimide group selectively reacts with thiol groups, allowing for the specific modification of proteins or other biomolecules that contain free thiols. The NHS ester group facilitates the conjugation reaction by reacting with primary amines. The PEG chain provides solubility and flexibility to the compound. Mal-amido-PEG6-NHS ester is commonly used in the development of antibody-drug conjugates and other bioconjugation applications.
| Catalog Number | I016731 |
| CAS Number | 1137109-21-7 |
| Molecular Formula | C₂₆H₃₉N₃O₁₃ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
