Mal-amido-PEG7-acid

• CAT Number: I016338
• CAS Number: 2112731-42-5
• Molecular Formula: C₂₄H₄₀N₂O₁₂
• Molecular Weight: 548.58
• Purity: ≥95%
• Target: PROTAC Linkers

Mal-amido-PEG7-acid(CAT: I016338) stands as a pivotal component in the synthesis of PROTACs. This PEG-based linker, characterized by its molecular structure, serves as a crucial bridge connecting the ligand for the protein of interest with the ligand for E3 ubiquitin ligase. Through its strategic design, Mal-amido-PEG7-acid enables the creation of PROTAC molecules, which harness the cell’s natural degradation machinery to selectively target and degrade specific proteins of interest.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562