For research use only. Not for therapeutic Use.
Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I045312 |
| CAS Number | 174422-72-1 |
| Synonyms | 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carbohydrazide;hydrochloride |
| Molecular Formula | C12H18ClN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H17N3O3.ClH/c13-14-12(18)9-3-1-8(2-4-9)7-15-10(16)5-6-11(15)17;/h5-6,8-9H,1-4,7,13H2,(H,14,18);1H |
| InChIKey | CKGAFBJFAXITJV-UHFFFAOYSA-N |
| SMILES | C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)NN.Cl |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
