Mal-C5-N-bis(PEG2-C2-acid)

• CAT Number: I040191
• CAS Number: 3026691-12-0
• Molecular Formula: C24H38N2O11
• Molecular Weight: 530.57
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethyl-[6-(2,5-dioxopyrrol-1-yl)hexanoyl]amino]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C24H38N2O11/c27-20(4-2-1-3-9-26-21(28)5-6-22(26)29)25(10-14-36-18-16-34-12-7-23(30)31)11-15-37-19-17-35-13-8-24(32)33/h5-6H,1-4,7-19H2,(H,30,31)(H,32,33)
• InChIKey: OCGSASUSCDQIMT-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCCCCC(=O)N(CCOCCOCCC(=O)O)CCOCCOCCC(=O)O

Mal-C5-N-bis(PEG2-C2-acid) (Cat No.: I040191) is a chemical compound designed for use in bioconjugation and drug delivery applications. It features a maleimide group (Mal) for thiol-specific conjugation, a C5 linker, and two PEG2-C2-acid units, which provide solubility and enhance pharmacokinetics. This structure is useful for linking proteins, antibodies, or other biomolecules to therapeutic agents or diagnostic tools, improving their stability and targeting efficiency. Its applications include developing targeted therapies for diseases such as cancer or for enhancing molecular imaging techniques.

Reference

[1]. Mark Frigerio, et al. The Chemical Design and Synthesis of Linkers Used in Antibody Drug Conjugates. Curr Top Med Chem. 2017;17(32):3393-3424.
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