Mal-C6-amine TFA

• CAT Number: I015625
• CAS Number: 731862-92-3
• Molecular Formula: C₁₂H₁₇F₃N₂O₄
• Molecular Weight: 310.27
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: Room temperature
• IUPAC Name: 1-(6-aminohexyl)pyrrole-2,5-dione;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C10H16N2O2.C2HF3O2/c11-7-3-1-2-4-8-12-9(13)5-6-10(12)14;3-2(4,5)1(6)7/h5-6H,1-4,7-8,11H2;(H,6,7)
• InChIKey: RBQIUIPYPXTLRY-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCCCCCN.C(=O)(C(F)(F)F)O

Mal-C6-amine (Cat No.:I015625) is an alkyl chain-based linker widely employed in the synthesis of proteolysis-targeting chimera (PROTAC) molecules. It consists of a maleimide group for conjugation to thiol-containing molecules and a C6 alkyl chain for spacer length and flexibility. This linker enables the connection between target protein binders (such as small molecules or antibodies) and E3 ligase ligands, leading to the targeted degradation of specific proteins. Mal-C6-amine (TFA) provides versatility in the design and synthesis of PROTACs, facilitating the development of novel therapeutics with potential applications in various diseases.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562