Mal-PEG1-Boc

For research use only. Not for therapeutic Use.

  • CAT Number: I016306
  • CAS Number: 810677-16-8
  • Molecular Formula: C13H19NO5
  • Molecular Weight: 269.29
  • Purity: ≥95%
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Mal-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].


Catalog Number I016306
CAS Number 810677-16-8
Synonyms

tert-butyl 3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoate

Molecular Formula C13H19NO5
Purity ≥95%
InChI InChI=1S/C13H19NO5/c1-13(2,3)19-12(17)6-8-18-9-7-14-10(15)4-5-11(14)16/h4-5H,6-9H2,1-3H3
InChIKey YFNQRZMVQPRONS-UHFFFAOYSA-N
SMILES CC(C)(C)OC(=O)CCOCCN1C(=O)C=CC1=O
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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