Mal-PEG1-NHS ester

• CAT Number: I017128
• CAS Number: 1807518-72-4
• Molecular Formula: C₁₃H₁₄N₂O₇
• Molecular Weight: 310.26
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-(2,5-dioxopyrrol-1-yl)ethoxy]propanoate
• InChI: InChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2
• InChIKey: AMRJPIJPLBUEHO-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCN2C(=O)C=CC2=O

Mal-PEG1-NHS ester（Cat No.:I017128） is a cleavable linker commonly employed in the construction of antibody-drug conjugates (ADCs). It consists of a maleimide group for conjugation with thiol-containing molecules, a PEG spacer for increased solubility and flexibility, and an NHS ester for reaction with primary amines. This linker enables the attachment of drugs to antibodies, facilitating targeted delivery of cytotoxic agents to specific cells. Additionally, Mal-PEG1-NHS ester can be utilized as a PEG-based PROTAC linker for the development of proteolysis-targeting chimeras (PROTACs).