For research use only. Not for therapeutic Use.
Mal-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I015720 |
| CAS Number | 34321-81-8 |
| Synonyms | 1-[2-(2-hydroxyethoxy)ethyl]pyrrole-2,5-dione |
| Molecular Formula | C8H11NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C8H11NO4/c10-4-6-13-5-3-9-7(11)1-2-8(9)12/h1-2,10H,3-6H2 |
| InChIKey | IIYLRYHFPWHINS-UHFFFAOYSA-N |
| SMILES | C1=CC(=O)N(C1=O)CCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
