For research use only. Not for therapeutic Use.
Mal-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I015723 |
| CAS Number | 1374666-31-5 |
| Synonyms | tert-butyl 3-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]propanoate |
| Molecular Formula | C15H23NO6 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H23NO6/c1-15(2,3)22-14(19)6-8-20-10-11-21-9-7-16-12(17)4-5-13(16)18/h4-5H,6-11H2,1-3H3 |
| InChIKey | XWPBPQDTQUEMBX-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCN1C(=O)C=CC1=O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
