Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan

• CAT Number: I040918
• CAS Number: 1599439-54-9
• Molecular Formula: C57H65FN10O15
• Molecular Weight: 1149.18
• Purity: ≥95%
• Synonyms: 4-[[2-[[(2S)-2-[[2-[[2-[3-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]propanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]butanamide
• InChI: InChI=1S/C57H65FN10O15/c1-3-57(80)37-25-42-53-35(30-68(42)55(78)36(37)31-83-56(57)79)52-39(12-11-34-32(2)38(58)26-40(66-53)51(34)52)64-45(71)10-7-17-59-46(72)28-63-54(77)41(24-33-8-5-4-6-9-33)65-48(74)29-62-47(73)27-61-44(70)16-20-81-22-23-82-21-18-60-43(69)15-19-67-49(75)13-14-50(67)76/h4-6,8-9,13-14,25-26,39,41,80H,3,7,10-12,15-24,27-31H2,1-2H3,(H,59,72)(H,60,69)(H,61,70)(H,62,73)(H,63,77)(H,64,71)(H,65,74)/t39-,41-,57-/m0/s1
• InChIKey: ZBYJQVQMEUURFL-APCOEFGTSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)CCCNC(=O)CNC(=O)C(CC7=CC=CC=C7)NC(=O)CNC(=O)CNC(=O)CCOCCOCCNC(=O)CCN8C(=O)C=CC8=O)O

Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan(CAT: I040918) is a conjugate composed of a malemide (Mal) group linked to a polyethylene glycol (PEG) spacer, followed by a peptide sequence (Gly-Gly-Phe-Gly) and the cytotoxic agent Exatecan. The PEG spacer enhances the solubility and stability of the compound, allowing for improved delivery and reduced off-target effects. Exatecan is a topoisomerase I inhibitor, which interferes with DNA replication and transcription, leading to cell death. This conjugate is designed for targeted cancer therapy, where the peptide sequence may facilitate selective binding to cancer cells, while Exatecan induces DNA damage. It is particularly relevant for Cancer Disease Research, offering a novel approach in targeted chemotherapy.