Mal-PEG3-NHS ester

• CAT Number: I017786
• CAS Number: 1537892-36-6
• Molecular Formula: C₁₇H₂₂N₂O₉
• Molecular Weight: 398.36
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C17H22N2O9/c20-13-1-2-14(21)18(13)6-8-26-10-12-27-11-9-25-7-5-17(24)28-19-15(22)3-4-16(19)23/h1-2H,3-12H2
• InChIKey: IIXXEVQHRSMNOB-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCN2C(=O)C=CC2=O

Mal-PEG3-NHS ester（Cat No.:I017786）, also known as maleimide-PEG3-NHS ester, is a linker molecule used in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates. It consists of a maleimide group for conjugation to thiol-containing molecules, a 3-unit polyethylene glycol (PEG) spacer, and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines. The PEG spacer provides flexibility and hydrophilicity to the conjugates, improving their solubility and stability. Mal-PEG3-NHS ester is commonly used to link therapeutic agents to antibodies or other targeting molecules, enabling targeted drug delivery and enhancing therapeutic outcomes.

Reference

[1]. Gautam S, et al. Immobilization of hydrophobic peptidic ligands to hydrophilic chromatographic matrix: a preconcentration approach. Anal Biochem. 2012 Apr 15;423(2):202-9.