Mal-PEG4-Val-Cit-PAB-PNP

• CAT Number: I016103
• CAS Number: 2112738-09-5
• Molecular Formula: C₄₀H₅₃N₇O₁₅
• Molecular Weight: 871.89
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[3-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C40H53N7O15/c1-27(2)36(45-33(48)15-18-57-20-22-59-24-25-60-23-21-58-19-17-46-34(49)13-14-35(46)50)38(52)44-32(4-3-16-42-39(41)53)37(51)43-29-7-5-28(6-8-29)26-61-40(54)62-31-11-9-30(10-12-31)47(55)56/h5-14,27,32,36H,3-4,15-26H2,1-2H3,(H,43,51)(H,44,52)(H,45,48)(H3,41,42,53)/t32-,36-/m0/s1
• InChIKey: ZEPYLTPLLQQBNX-IKYOIFQTSA-N
• SMILES: CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCOCCOCCOCCOCCN3C(=O)C=CC3=O

Mal-PEG4-Val-Cit-PAB-PNP（Cat No.:I016103） is a cleavable 4-unit polyethylene glycol (PEG) linker used in the synthesis of antibody-drug conjugates (ADCs). It serves as a bridge between the antibody and the attached drug payload. The linker is designed to be stable in circulation but undergoes selective cleavage in target cells, enabling the release of the drug payload at the desired site. This controlled release mechanism enhances the efficacy and specificity of the ADC, facilitating the targeted delivery of potent cytotoxic drugs to cancer cells while minimizing off-target effects.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.