Mal-PEG5-acid

• CAT Number: I017120
• CAS Number: 1286755-26-7
• Molecular Formula: C17H27NO9
• Molecular Weight: 389.40
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C17H27NO9/c19-15-1-2-16(20)18(15)4-6-24-8-10-26-12-14-27-13-11-25-9-7-23-5-3-17(21)22/h1-2H,3-14H2,(H,21,22)
• InChIKey: HFYDLVZXYONWDG-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCC(=O)O

Mal-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.