For research use only. Not for therapeutic Use.
Mal-PEG5-PFP ester（Cat No.:I016305）is a bifunctional chemical compound consisting of three key components: maleimide (Mal), polyethylene glycol (PEG) with five ethylene glycol units, and a pentafluorophenyl (PFP) ester group. The maleimide group allows for specific covalent bonding to thiol groups in proteins or peptides, making it useful in bioconjugation applications. The PEG linker provides increased solubility and stability, while the PFP ester group facilitates efficient coupling reactions. This compound is commonly used in drug delivery, targeted therapies, and molecular biology for the development of bioconjugates and site-specific labeling in various research applications.
| Catalog Number | I016305 |
| CAS Number | 1807512-46-4 |
| Molecular Formula | C₂₃H₂₆F₅NO₉ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| IUPAC Name | (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| InChI | InChI=1S/C23H26F5NO9/c24-18-19(25)21(27)23(22(28)20(18)26)38-17(32)3-5-33-7-9-35-11-13-37-14-12-36-10-8-34-6-4-29-15(30)1-2-16(29)31/h1-2H,3-14H2 |
| InChIKey | HVQHYQSUANAJJW-UHFFFAOYSA-N |
| SMILES | C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCC(=O)OC2=C(C(=C(C(=C2F)F)F)F)F |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
