Mal-PEG6-NHS ester

• CAT Number: I017762
• CAS Number: 1599472-25-9
• Molecular Formula: C₂₃H₃₄N₂O₁₂
• Molecular Weight: 530.52
• Purity: ≥95%
• Target: ADC Linker
• Storage: 2-8°C
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C23H34N2O12/c26-19-1-2-20(27)24(19)6-8-32-10-12-34-14-16-36-18-17-35-15-13-33-11-9-31-7-5-23(30)37-25-21(28)3-4-22(25)29/h1-2H,3-18H2
• InChIKey: UUNUCVXNAHYFJP-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCN2C(=O)C=CC2=O

Mal-PEG6-NHS ester（Cat No.:I017762）, also known as maleimide-PEG6-NHS ester, is a linker molecule commonly used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimide group for conjugation to thiol-containing molecules, a 6-unit polyethylene glycol (PEG) spacer, and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines. This linker provides stability and flexibility to ADCs while facilitating efficient drug release at the target site. Mal-PEG6-NHS ester is widely used in the field of targeted drug delivery to enhance the therapeutic efficacy of anticancer agents.

Reference

[1]. Kennett Sprogøe , et al. Relaxin prodrugs. WO2015067791A1.