Mal-PEG8-Val-Ala-PAB-Exatecan

• CAT Number: I043407
• CAS Number: 2679821-39-5
• Molecular Formula: C66H85FN8O20
• Molecular Weight: 1329.42
• Purity: ≥95%
• IUPAC Name: [4-[[(2S)-2-[[(2S)-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamate
• InChI: InChI=1S/C66H85FN8O20/c1-6-66(85)48-35-52-60-46(37-75(52)63(82)47(48)39-94-64(66)83)58-50(12-11-45-41(4)49(67)36-51(71-60)57(45)58)72-65(84)95-38-43-7-9-44(10-8-43)70-61(80)42(5)69-62(81)59(40(2)3)73-54(77)16-19-86-21-23-88-25-27-90-29-31-92-33-34-93-32-30-91-28-26-89-24-22-87-20-17-68-53(76)15-18-74-55(78)13-14-56(74)79/h7-10,13-14,35-36,40,42,50,59,85H,6,11-12,15-34,37-39H2,1-5H3,(H,68,76)(H,69,81)(H,70,80)(H,72,84)(H,73,77)/t42-,50-,59-,66-/m0/s1
• InChIKey: KMNDIRZLBCQRRP-MZMRBSGUSA-N
• SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)OCC7=CC=C(C=C7)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN8C(=O)C=CC8=O)O

Mal-PEG8-Val-Ala-PAB-Exatecan（Cat No.:I043407）is a conjugated molecule used in targeted drug delivery systems, particularly for cancer therapy. It consists of several components: Mal (maleimide), PEG8 (a polyethylene glycol linker), Val-Ala (a dipeptide sequence for peptide-based targeting), PAB (a spacer), and Exatecan, a potent topoisomerase I inhibitor used in chemotherapy. The maleimide group allows for specific conjugation to thiol-containing molecules, enhancing the targeted delivery of Exatecan to cancer cells. This approach aims to improve the therapeutic efficacy of Exatecan while minimizing off-target effects and toxicity in healthy tissues.