Mal-Val-Ala-PABA-cGAMP

• CAT Number: I042390
• Molecular Formula: C46H56N14O20P2
• Molecular Weight: 1186.97
• Purity: ≥95%
• Synonyms: [4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl N-[9-[(1S,6R,8R,9R,10S,15R,17R,18R)-17-(2-amino-6-oxo-1H-purin-9-yl)-3,9,12,18-tetrahydroxy-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.3.0.06,10]octadecan-8-yl]purin-6-yl]carbamate

Mal-Val-Ala-PABA-cGAMP（Cat No.:I042390）is a synthetic compound designed to enhance immune responses, particularly in cancer immunotherapy. It consists of a maleimide (Mal) group for conjugation to targeting agents, a Val-Ala peptide linker for stability, and para-aminobenzoic acid (PABA) as a spacer. The key component, cyclic GMP-AMP (cGAMP), is a potent stimulator of the STING pathway, which triggers immune activation and promotes antitumor immunity. This prodrug can be activated at the target site, improving the delivery of cGAMP and enhancing immune-mediated tumor destruction while minimizing systemic side effects.