MALAT1-IN-1

• CAT Number: I017976
• CAS Number: 827327-28-6
• Molecular Formula: C19H21N3O2
• Molecular Weight: 323.39
• Purity: ≥95%
• Synonyms: 5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methylimidazol-2-amine
• InChI: InChI=1S/C19H21N3O2/c1-22-18(15-7-9-16(23-2)10-8-15)13-21-19(22)20-12-14-5-4-6-17(11-14)24-3/h4-11,13H,12H2,1-3H3,(H,20,21)
• InChIKey: LCVOJBGSGIOMKF-UHFFFAOYSA-N
• SMILES: CN1C(=CN=C1NCC2=CC(=CC=C2)OC)C3=CC=C(C=C3)OC

MALAT1-IN-1 (compounds 5) is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting expression of nuclear enriched abundant transcript 1 (Neat1) [1].
MALAT1-IN-1 (Compound 5) (1 μM, 7 days) reduces Malat1 levels and mammary tumor organoid branching in an organoid model of mammary cancer derived from MMTV-PyMT luminal B tumors in mice[1].
MALAT1-IN-1 (0.5 and 1 μM) inhibits downstream targets of Malat1 (krt16) and increases csn2 in MMTV-PyMT tumor organoids[1].

Reference

[1]. Abulwerdi FA, et al. Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chem Biol. 2019 Feb 15;14(2):223-235.
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