Maleimido-tri(ethylene glycol)-propionic acid

• CAT Number: I017000
• CAS Number: 518044-40-1
• Molecular Formula: C₁₃H₁₉NO₇
• Molecular Weight: 301.29
• Purity: ≥95%
• IUPAC Name: 3-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C13H19NO7/c15-11-1-2-12(16)14(11)4-6-20-8-10-21-9-7-19-5-3-13(17)18/h1-2H,3-10H2,(H,17,18)
• InChIKey: YSFOTVPQFVYTQX-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCOCCOCCOCCC(=O)O

Maleimido-tri(ethylene glycol)-propionic acid (Cat No.:I017000) is a degradable ADClinker for the synthesis of antibody-drug conjugates. Maleimido-tri(ethylene glycol)-propionic acid was used in the preparation of neolymphostin-based ADC precursors for conjugation of the site-specific cysteine mutant trastuzumab-A114C. Maleimido-tri(ethylene glycol)-propionic acid can also be used as a PEG-based PROTACLinker for the synthesis of PROTACs.

Reference

[1]. Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.