For research use only. Not for therapeutic Use.
Malonyl coenzyme A is a coenzyme A (CoA; Item No. <span class=/itemid/>16147</span>) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. <span class=/itemid/>16160</span>). Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis. Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.
| Catalog Number | M011351 |
| CAS Number | 108347-84-8 |
| Synonyms | Malonyl-CoA |
| Molecular Formula | C24H38N7O19P3S • XLi |
| Purity | ≥95% |
| Target | Mitochondrial Metabolism |
| Storage | -20°C |
| InChIKey | OPIJLICRFQMMJH-VYLCMXPPSA-N |
