For research use only. Not for therapeutic Use.
Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.<br>Malotilate at concentrations of 0.1–100 μM increases collagenase activity in a concentration-dependent manner in the multilayered cultures, but not in the monolayers. Malotilate increases the secretion of MMP-1 and MMP-3 in the wounded multilayered cultures, but not in the wounded monolayers.<br>Malotilate suppresses pulmonary metastasis and lung metastasis in rats.
| Catalog Number | A000776 |
| CAS Number | 59937-28-9 |
| Synonyms | NKK105 |
| Molecular Formula | C12H16O4S2 |
| Purity | ≥95% |
| Target | Lipoxygenase |
| Solubility | >14.4mg/mL in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate |
| InChI | InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-8H,1-4H3 |
| InChIKey | YPIQVCUJEKAZCP-UHFFFAOYSA-N |
| SMILES | CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C |
