Manidipine dihydrochloride

• CAT Number: I005342
• CAS Number: 89226-75-5
• Molecular Formula: C35H40Cl2N4O6
• Molecular Weight: 683.62
• Purity: ≥95%
• Synonyms: 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;dihydrochloride
• Target: Calcium Channel
• Solubility: DMSO 20 mg/mL
• Storage: 3 years -20C powder
• IC50: 2.6 nM

Manidipine dihydrochloride (CAT: I005342), also known as Manidipine 2HCl or CV-4093, is a dihydropyridine compound that serves as a potent calcium channel blocker. Its pharmacological action involves inhibiting Ca2+ currents with an impressive IC50 value of 2.6 nM. By blocking calcium channels, Manidipine dihydrochloride reduces the influx of calcium ions into cells, leading to vasodilation and a decrease in blood pressure. This compound’s role as a calcium channel blocker highlights its significance in cardiovascular medicine, where it offers potential therapeutic applications in the management of hypertension and other cardiovascular conditions.

Reference

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