Manumycin A

• CAT Number: R023597
• CAS Number: 52665-74-4
• Molecular Formula: C₃₁H₃₈N₂O
• Molecular Weight: 550.64
• Purity: ≥95%
• Synonyms: (2E,4E,6R)-N-[(1S,5S,6R)-5-Hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-2,4-decadienamide; (2E,4E,6R)-N-[(1S,5S,6R)-5-Hydroxy-5-[(1E,3E,5E)-7
• Target: MAPK/ERK Pathway
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (2E,4E,6R)-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopenten-1-yl)amino]-7-oxohepta-1,3,5-trienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyldeca-2,4-dienamide
• InChI: InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
• InChIKey: TWWQHCKLTXDWBD-MVTGTTCWSA-N
• SMILES: CCCC[C@@H](C)/C=C(\C)/C=C(\C)/C(=O)NC1=C[C@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

Manumycin A (Cat No.:R023597) is a natural compound with potential applications in pharmacology and biomedical research. It targets the enzyme farnesyltransferase, inhibiting the prenylation of proteins crucial for proper cellular localization and function. By disrupting the prenylation process, Manumycin A may affect the signaling pathways and functions of prenylated proteins. It has been studied for potential applications in cancer research, as certain cancer-related proteins rely on prenylation for their activity. Additionally, it shows promise in other areas such as inflammation and infectious diseases, where prenylation plays significant roles.