For research use only. Not for therapeutic Use.
MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures[1].
MAO-B-IN-18 (compound 20; 0.1, 0.5, 1, 5 μM) at low concentration proves to be able to protect neuroblastoma cells from pro-oxidant insults through ROS-scavenging pathways at a moderate level in SH-SY5Y cells[1].
MAO-B-IN-18 (5 μM) co-incubated at with hydrogen peroxide (400 μM) maintains viable cells at a level comparable to that of Quercetin (HY-18085) used as positive control at higher doses (75 μM) in DI TNC1 astrocyte cell line[1].
| Catalog Number | I041229 |
| Synonyms | 5-(1H-indazol-5-yl)-3-[4-[(3,4,5-trimethoxyphenyl)methoxy]phenyl]-1,2,4-oxadiazole |
| Molecular Formula | C25H22N4O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H22N4O5/c1-30-21-10-15(11-22(31-2)23(21)32-3)14-33-19-7-4-16(5-8-19)24-27-25(34-29-24)17-6-9-20-18(12-17)13-26-28-20/h4-13H,14H2,1-3H3,(H,26,28) |
| InChIKey | MMVVUYZEFSZMKK-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)COC2=CC=C(C=C2)C3=NOC(=N3)C4=CC5=C(C=C4)NN=C5 |
| Reference | [1]. Mariagrazia Rullo, et al. Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors. Eur J Med Chem. 2023 Jul 5;255:115352. |
