marinobufagenin

• CAT Number: R000002
• CAS Number: 470-42-8
• Molecular Formula: C24H32O5
• Molecular Weight: 400.515
• Purity: ≥95%
• Synonyms: Marinobufagin;Marinobufogenin;marinobufagenin;3β,5β-Dihydroxy-14β,15β-epoxybufa-20,22-dienolide;3β,5-Dihydroxy-14,15β-epoxy-5β-bufa-20,22-dienolide;14,15β-Epoxy-3β,5-dihydroxy-5β-bufa-20,22-dienolide
• Target: Na+/K+ ATPase
• Solubility: Insoluble in water
• Storage: -20oC
• IUPAC Name: 5-[(1R,2S,4R,6R,7R,10S,11R,14S,16S)-14,16-dihydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one
• InChI: InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1
• InChIKey: JMNQTHQLNRILMH-OBBGIPBRSA-N
• SMILES: CC12CCC(CC1(CCC3C2CCC4(C35C(O5)CC4C6=COC(=O)C=C6)C)O)O

Marinobufagenin is a naturally occurring cardiotonic steroid (CTS) that is structurally related to digitalis-like compounds. It is derived from amphibian skin, specifically from toads of the Bufonidae family, and has also been detected in mammals, including humans. Marinobufagenin inhibits the sodium-potassium ATPase (Na⁺/K⁺-ATPase) pump, leading to an increase in intracellular sodium and calcium concentrations, which enhances cardiac contractility. It is studied for its role in regulating blood pressure and its involvement in conditions such as hypertension, heart failure, and preeclampsia. Marinobufagenin’s ability to influence cardiovascular function makes it a target of interest in both medical research and therapeutic drug development.