For research use only. Not for therapeutic Use.
MARK4 inhibitor 1 is a potent and selective microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis[1].
MARK4 inhibitor 1 (compound 9g; 0-200 µM ; 24-48 h) shows inhibition of cell proliferation and cell migration[1].
MARK4 inhibitor 1 (compound 9g; 24) induces apoptosis in these cancerous cells, with IC50 values of 6.22 μM, 9.94 μM and 8.14 μM, respectively[1].
| Catalog Number | I046207 |
| CAS Number | 2271081-58-2 |
| Synonyms | N-[(2-hydroxy-7-methyl-1H-indol-3-yl)imino]-1-[(4-methoxyphenyl)methyl]triazole-4-carboxamide |
| Molecular Formula | C20H18N6O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H18N6O3/c1-12-4-3-5-15-17(12)21-20(28)18(15)23-24-19(27)16-11-26(25-22-16)10-13-6-8-14(29-2)9-7-13/h3-9,11,21,28H,10H2,1-2H3 |
| InChIKey | KACGMLSYPGROFF-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=CC=C1)C(=C(N2)O)N=NC(=O)C3=CN(N=N3)CC4=CC=C(C=C4)OC |
| Reference | [1]. Aneja B, et al. Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem. 2019 Feb 1;163:840-852. |
