Maropitant Citrate Salt

• CAT Number: R057955
• CAS Number: 862543-54-2
• Molecular Formula: C38H48N2O8
• Molecular Weight: 660.808
• Purity: ≥95%
• Synonyms: (2S-cis)-N-[[5-(1,1-Dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine Citrate Salt; (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Salt; Cerenia
• Storage: Store at -20°C
• IUPAC Name: (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;2-hydroxypropane-1,2,3-tricarboxylic acid
• InChI: InChI=1S/C32H40N2O.C6H8O7/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t30-,31-;/m0./s1
• InChIKey: XDZPFSKCXRGRIO-PNXDLZEOSA-N
• SMILES: CC(C)(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Maropitant Citrate Salt (CAS 862543-54-2) is a selective neurokinin 1 receptor (NK1) antagonist for prevention of vomiting due to motion sickness in dogs.

Reference

1.Rau SE, et al. J Vet Intern Med. 2010 Nov-Dec;24(6):1452-7.
2.Pang, Daniel SJ. "Anesthetic and analgesic adjunctive drugs." Veterinary Anesthesia and Analgesia: Lumb & Jones. 5th ed. Ames, Iowa: Blackwell Publishing (2015): 244-259.
3.Marquez, Megan, et al. "Comparison of nk-1 receptor antagonist (maropitant) to morphine as a pre-anaesthetic agent for canine ovariohysterectomy." PLoS One 10.10 (2015): e0140734.