For research use only. Not for therapeutic Use.
Martinostat (hydrochloride) is a inhibitor of HDAC that can be labeled with radionuclides for diagnostic applications[1][2].
| Catalog Number | I040213 |
| Synonyms | (E)-3-[4-[[1-adamantylmethyl(methyl)amino]methyl]phenyl]-N-hydroxyprop-2-enamide;hydrochloride |
| Molecular Formula | C22H31ClN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H30N2O2.ClH/c1-24(14-17-4-2-16(3-5-17)6-7-21(25)23-26)15-22-11-18-8-19(12-22)10-20(9-18)13-22;/h2-7,18-20,26H,8-15H2,1H3,(H,23,25);1H/b7-6+; |
| InChIKey | MRSVJZJSPMLBEO-UHDJGPCESA-N |
| SMILES | CN(CC1=CC=C(C=C1)C=CC(=O)NO)CC23CC4CC(C2)CC(C4)C3.Cl |
| Reference | [1]. Changning Wang, et al. In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs. J Med Chem. 2014 Oct 9;57(19):7999-8009. [2]. Tharick A Pascoal, et al. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease. Nat Commun. 2022 Jul 19;13(1):4171. |
