MASM7

• CAT Number: I043229
• CAS Number: 920868-45-7
• Molecular Formula: C22H23N5O2S2
• Molecular Weight: 453.58
• Purity: ≥95%
• Synonyms: 2-[2-[(5-cyclopropyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]propanoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
• InChI: InChI=1S/C22H23N5O2S2/c1-12(20(29)24-21-17(18(23)28)15-8-5-9-16(15)31-21)30-22-26-25-19(13-10-11-13)27(22)14-6-3-2-4-7-14/h2-4,6-7,12-13H,5,8-11H2,1H3,(H2,23,28)(H,24,29)
• InChIKey: MTAWXPCGCQTSOJ-UHFFFAOYSA-N
• SMILES: CC(C(=O)NC1=C(C2=C(S1)CCC2)C(=O)N)SC3=NN=C(N3C4=CC=CC=C4)C5CC5

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1].
MASM7 (1-10 μM, 2 h) increases Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN[1].
MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1].
MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines[1].
MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h[1].
MASM7 (1 μΜ, 6 h) does not induce caspase-3/7 activation in U2OS cells[1].
MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs[1].

Reference

[1]. Emmanouil Zacharioudakis, et al. Modulating mitofusins to control mitochondrial function and signaling. Nat Commun. 2022 Jul 7;13(1):3775.
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