MAT2A inhibitor 3

• CAT Number: I044448
• CAS Number: 2439271-82-4
• Molecular Formula: C16H14ClN3O
• Molecular Weight: 299.75
• Purity: ≥95%
• Synonyms: 7-chloro-4-(dimethylamino)-1-phenylquinazolin-2-one
• InChI: InChI=1S/C16H14ClN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3
• InChIKey: JMLJEYLWRAPHBL-UHFFFAOYSA-N
• SMILES: CN(C)C1=NC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3

MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1, compound 24, has an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers[1].
MAT2A inhibitor 3 is a potent methionine adenosyltransferase 2A inhibitor, with an IC50 of <200 nM[1].

Reference

[1]. Alam M, et, al. 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors. WO2020123395A1.