For research use only. Not for therapeutic Use.
MAX-10181 (PD-1/PD-L1-IN-30) is a PD-1/PD-L1 binding inhibitor, with an IC50 value of 0.018 μM. MAX-10181 can be used for research of cancers and other related diseases[1].
MAX-10181 (Example 68) inhibits PD-1/PD-L1 binding with an IC50 value of 0.018 μM[1].
| Catalog Number | I041714 |
| CAS Number | 2171558-14-6 |
| Synonyms | 2-[[3-[(E)-2-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]ethenyl]-4-(trifluoromethyl)phenyl]methylamino]-3-hydroxy-2-methylpropanoic acid |
| Molecular Formula | C29H28F3NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H28F3NO5/c1-18-20(4-3-5-23(18)21-9-11-25-26(15-21)38-13-12-37-25)7-8-22-14-19(6-10-24(22)29(30,31)32)16-33-28(2,17-34)27(35)36/h3-11,14-15,33-34H,12-13,16-17H2,1-2H3,(H,35,36)/b8-7+ |
| InChIKey | PTGUEPRQUFAZLN-BQYQJAHWSA-N |
| SMILES | CC1=C(C=CC=C1C2=CC3=C(C=C2)OCCO3)C=CC4=C(C=CC(=C4)CNC(C)(CO)C(=O)O)C(F)(F)F |
| Reference | [1]. Wang, Yuguang, et al. Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof. Patent. WO2018006795. |
