For research use only. Not for therapeutic Use.
Maytansinol (Cat No.:I004129) is a naturally occurring compound derived from the Maytenus species of plants. It belongs to the class of maytansinoids known for their potent cytotoxicity and antitumor activity. Maytansinol acts by inhibiting microtubule assembly and disrupting mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells. Due to its cytotoxic effects, maytansinol has been investigated as a potential anticancer agent and has shown promising results in preclinical studies. However, its clinical development has been limited due to its poor solubility and toxicity. Maytansinol is an important compound for developing novel cytotoxic agents and targeted drug delivery systems in cancer therapy.
| Catalog Number | I004129 |
| CAS Number | 57103-68-1 |
| Synonyms | Maytansinol; Ansamitocin P-0; SCHEMBL13558643; EX-A2656 |
| Molecular Formula | C28H37ClN2O8 |
| Purity | ≥95% |
| Target | Microtubule/Tubulin |
| Solubility | DMSO: ≥ 35 mg/mL |
| Storage | Store at -20C |
| IUPAC Name | (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaene-8,23-dione |
| InChI | InChI=1S/C28H37ClN2O8/c1-15-8-7-9-22(37-6)28(35)14-20(38-26(34)30-28)16(2)25-27(3,39-25)21(32)13-23(33)31(4)18-11-17(10-15)12-19(36-5)24(18)29/h7-9,11-12,16,20-22,25,32,35H,10,13-14H2,1-6H3,(H,30,34)/b9-7+,15-8+/t16-,20+,21+,22-,25+,27+,28+/m1/s1 |
| InChIKey | QWPXBEHQFHACTK-RZKXNLMUSA-N |
| SMILES | CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)O)C)C)OC)(NC(=O)O2)O |
| Reference | <p style=”/line-height:25px/”> |
