For research use only. Not for therapeutic Use.
MB725（Cat No.:I031621）is an investigational small molecule inhibitor of the protein kinase Akt, which plays a critical role in cell survival, growth, and metabolism. Akt is frequently overactivated in various cancers, promoting tumor cell proliferation and resistance to chemotherapy. By inhibiting Akt, MB725 aims to disrupt these oncogenic pathways and enhance the effectiveness of existing cancer therapies. Preclinical studies have shown that MB725 can reduce tumor growth and increase sensitivity to other anticancer treatments, particularly in solid tumors and hematological malignancies. Clinical trials are ongoing to evaluate its safety, efficacy, and potential therapeutic applications in oncology.
| Catalog Number | I031621 |
| CAS Number | 2230058-99-6 |
| Synonyms | MB-725; MB 725; MB725 |
| Molecular Formula | C18H21IN4O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-(diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-pyrrol-1-yl-1,3-benzothiazole-4-carboxamide |
| InChI | InChI=1S/C18H21IN4O2S/c1-4-20-17(25)11-13-16(26-18(21-13)22(5-2)6-3)14(12(19)15(11)24)23-9-7-8-10-23/h7-10,24H,4-6H2,1-3H3,(H,20,25) |
| InChIKey | GBNAUQMZRRFQTA-UHFFFAOYSA-N |
| SMILES | CCNC(=O)C1=C2C(=C(C(=C1O)I)N3C=CC=C3)SC(=N2)N(CC)CC |
| Reference | 1: Baud MGJ, Bauer MR, Verduci L, Dingler FA, Patel KJ, Horil Roy D, Joerger AC, Fersht AR. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114. doi: 10.1016/j.ejmech.2018.04.035. Epub 2018 Apr 21. PubMed PMID: 29702446; PubMed Central PMCID: PMC5986712. |
