MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan

• CAT Number: I043343
• CAS Number: 2414254-41-2
• Molecular Formula: C54H58FN9O13
• Molecular Weight: 1060.09
• Purity: ≥95%
• Synonyms: 1-[[[2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]-N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]cyclopropane-1-carboxamide
• InChI: InChI=1S/C54H58FN9O13/c1-3-54(75)34-21-39-48-32(26-64(39)50(72)33(34)27-76-52(54)74)47-36(14-13-31-29(2)35(55)22-37(61-48)46(31)47)62-51(73)53(17-18-53)77-28-59-42(67)24-58-49(71)38(20-30-10-6-4-7-11-30)60-43(68)25-57-41(66)23-56-40(65)12-8-5-9-19-63-44(69)15-16-45(63)70/h4,6-7,10-11,15-16,21-22,36,38,75H,3,5,8-9,12-14,17-20,23-28H2,1-2H3,(H,56,65)(H,57,66)(H,58,71)(H,59,67)(H,60,68)(H,62,73)/t36-,38-,54-/m0/s1
• InChIKey: NGEGCXGRKSPISA-IJZYVGEDSA-N
• SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)C7(CC7)OCNC(=O)CNC(=O)[C@H](CC8=CC=CC=C8)NC(=O)CNC(=O)CNC(=O)CCCCCN9C(=O)C=CC9=O)O

MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan（Cat No.:I043343）is a targeted peptide-drug conjugate designed for cancer therapy. The compound features a peptide sequence (MC-Gly-Gly-Phe-Gly-amide) that directs the cytotoxic agent Exatecan to cancer cells. Exatecan, a potent topoisomerase I inhibitor, is linked via a cyclopropanol-amide bond, which is cleaved upon cellular uptake. This allows Exatecan to specifically target and inhibit DNA replication in tumor cells, leading to cell death. The selective delivery of Exatecan to cancer cells enhances therapeutic efficacy while minimizing off-target effects, making this conjugate a promising candidate for cancer treatment.