MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan

• CAT Number: I042917
• CAS Number: 2414393-22-7
• Molecular Formula: C55H60FN9O13
• Molecular Weight: 1074.12
• Purity: ≥95%
• Synonyms: 1-[[[2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]-N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]cyclobutane-1-carboxamide
• InChI: InChI=1S/C55H60FN9O13/c1-3-55(76)35-22-40-49-33(27-65(40)51(73)34(35)28-77-53(55)75)48-37(15-14-32-30(2)36(56)23-38(62-49)47(32)48)63-52(74)54(18-10-19-54)78-29-60-43(68)25-59-50(72)39(21-31-11-6-4-7-12-31)61-44(69)26-58-42(67)24-57-41(66)13-8-5-9-20-64-45(70)16-17-46(64)71/h4,6-7,11-12,16-17,22-23,37,39,76H,3,5,8-10,13-15,18-21,24-29H2,1-2H3,(H,57,66)(H,58,67)(H,59,72)(H,60,68)(H,61,69)(H,63,74)/t37-,39-,55-/m0/s1
• InChIKey: DBCVGCVTFAJVMD-HKMBIKTJSA-N
• SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)C7(CCC7)OCNC(=O)CNC(=O)[C@H](CC8=CC=CC=C8)NC(=O)CNC(=O)CNC(=O)CCCCCN9C(=O)C=CC9=O)O

MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan（Cat No.:I042917）is a novel peptide-drug conjugate (PDC) designed to deliver targeted therapeutic agents to cancer cells. It consists of a peptide sequence (MC-Gly-Gly-Phe-Gly) that targets specific receptors on cancer cells, conjugated to Exatecan, a potent chemotherapy drug. Exatecan works by inhibiting topoisomerase I, preventing DNA replication and causing cancer cell death. The incorporation of cyclobutanecarboxylic acid improves the stability and specificity of the conjugate, enhancing its efficacy while minimizing off-target effects. This compound is being studied for its potential in targeted cancer therapy, offering more precise and effective treatment options.