MC-Gly-Gly-Phe

For research use only. Not for therapeutic Use.

  • CAT Number: I017657
  • CAS Number: 1599440-15-9
  • Molecular Formula: C₂₃H₂₈N₄O₇
  • Molecular Weight: 472.49
  • Purity: ≥95%
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MC-Gly-Gly-Phe(Cat No.:I017657) is a cleavable linker commonly used in the development of antibody drug conjugates (ADCs). It acts as a connector between the antibody and the cytotoxic payload. The linker is designed to be stable in circulation but undergo selective cleavage within the target cell, facilitating the release of the cytotoxic drug and enhancing its efficacy. MC-Gly-Gly-Phe offers a versatile and effective strategy for targeted drug delivery, improving the specificity and potency of ADCs in cancer therapy.


Catalog Number I017657
CAS Number 1599440-15-9
Molecular Formula C₂₃H₂₈N₄O₇
Purity ≥95%
Target ADC Linker
IUPAC Name (2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoic acid
InChI InChI=1S/C23H28N4O7/c28-18(9-5-2-6-12-27-21(31)10-11-22(27)32)24-14-19(29)25-15-20(30)26-17(23(33)34)13-16-7-3-1-4-8-16/h1,3-4,7-8,10-11,17H,2,5-6,9,12-15H2,(H,24,28)(H,25,29)(H,26,30)(H,33,34)/t17-/m0/s1
InChIKey NFVPAFLSJIPUCL-KRWDZBQOSA-N
SMILES C1=CC=C(C=C1)CC(C(=O)O)NC(=O)CNC(=O)CNC(=O)CCCCCN2C(=O)C=CC2=O
Reference

[1]. Antibody-drug conjugate. WO2014057687A1.

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