For research use only. Not for therapeutic Use.
Mc-MMAD (Cat No.:I001534) is a potent inhibitor of the enzyme methionine aminopeptidase 2 (MetAP2), which is involved in protein processing and angiogenesis. By inhibiting MetAP2, Mc-MMAD disrupts the removal of methionine from nascent proteins, influencing cellular functions and promoting apoptosis in cancer cells. This compound has shown efficacy in preclinical studies against various tumors, particularly in the context of anti-angiogenic therapies. Mc-MMAD’s mechanism of action and its potential therapeutic applications make it a significant focus in cancer research, particularly in developing targeted treatments for malignancies.
| Catalog Number | I001534 |
| CAS Number | 1401963-15-2 |
| Synonyms | (S,Z)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-N-((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R,Z)-3-hydroxy-1-methoxy-2-methyl-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)imino)propyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(met |
| Molecular Formula | C51H77N7O9S |
| Purity | ≥95% |
| Target | Microtubule/Tubulin |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 6-(2,5-dioxopyrrol-1-yl)-N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylhexanamide |
| InChI | InChI=1S/C51H77N7O9S/c1-12-34(6)46(56(9)51(65)44(32(2)3)54-49(64)45(33(4)5)55(8)40(59)23-17-14-18-27-58-41(60)24-25-42(58)61)39(66-10)31-43(62)57-28-19-22-38(57)47(67-11)35(7)48(63)53-37(50-52-26-29-68-50)30-36-20-15-13-16-21-36/h13,15-16,20-21,24-26,29,32-35,37-39,44-47H,12,14,17-19,22-23,27-28,30-31H2,1-11H3,(H,53,63)(H,54,64)/t34-,35+,37-,38-,39+,44-,45-,46-,47+/m0/s1 |
| InChIKey | OZUQLKHIIRUJRZ-PGBUMTRMSA-N |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN4C(=O)C=CC4=O |
| Reference | <p style=/line-height:25px/> |
