MC-Val-Ala-PAB-PNP

• CAT Number: I016168
• CAS Number: 1639939-40-4
• Molecular Formula: C₃₂H₃₇N₅O₁₀
• Molecular Weight: 651.66
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: [4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C32H37N5O10/c1-20(2)29(35-26(38)7-5-4-6-18-36-27(39)16-17-28(36)40)31(42)33-21(3)30(41)34-23-10-8-22(9-11-23)19-46-32(43)47-25-14-12-24(13-15-25)37(44)45/h8-17,20-21,29H,4-7,18-19H2,1-3H3,(H,33,42)(H,34,41)(H,35,38)/t21-,29-/m0/s1
• InChIKey: QXMLUPPUFBNKRY-LGGPFLRQSA-N
• SMILES: CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CCCCCN3C(=O)C=CC3=O

MC-Val-Ala-PAB-PNP（Cat No.:I016168） is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs). It is crucial in linking the antibody and the cytotoxic drug payload. The linker contains a valine-alanine dipeptide, a para-aminobenzyloxycarbonyl (PAB) spacer, and a p-nitrophenyl (PNP) group. This specific linker is designed to be stable during circulation but susceptible to enzymatic cleavage in the target cell, facilitating the release of the potent drug payload and enhancing the targeted delivery and efficacy of the ADC in cancer therapy.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.