For research use only. Not for therapeutic Use.
Mc-Val-Cit-PAB-Cl(Cat No.:I018284) is a degradable linker commonly used in the construction of antibody-drug conjugates (ADCs). It serves as a connection between the potent cytotoxic agent monomethyl auristatin E (MMAE) and antibodies, resulting in the formation of antibody-MC-vc-MMAE conjugates. For example, anti-CD22-MC-VC-PABC-MMAE formed with this linker exhibits potent cytotoxicity against BJAB and WSU cancer cells, with IC50 values of 3.3nM and 0.95nM, respectively. This linker facilitates targeted delivery of the cytotoxic agent, enhancing the therapeutic efficacy of ADCs in cancer treatment.
Catalog Number | I018284 |
CAS Number | 1639351-92-0 |
Molecular Formula | C₂₈H₃₉ClN₆O₆ |
Purity | ≥95% |
Target | ADC Linker |
IUPAC Name | N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(chloromethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide |
InChI | InChI=1S/C28H39ClN6O6/c1-18(2)25(34-22(36)8-4-3-5-16-35-23(37)13-14-24(35)38)27(40)33-21(7-6-15-31-28(30)41)26(39)32-20-11-9-19(17-29)10-12-20/h9-14,18,21,25H,3-8,15-17H2,1-2H3,(H,32,39)(H,33,40)(H,34,36)(H3,30,31,41)/t21-,25-/m0/s1 |
InChIKey | TUMQZNBKSWFFAZ-OFVILXPXSA-N |
SMILES | CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CCl)NC(=O)CCCCCN2C(=O)C=CC2=O |
Reference | [1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041. |