Mc-Val-Cit-PABC-PNP

• CAT Number: I002028
• CAS Number: 159857-81-5
• Molecular Formula: C35H43N7O11
• Molecular Weight: 737.76
• Purity: ≥95%
• Target: ADC Linker
• Solubility: DMSO: ≥ 37 mg/mL
• Storage: -20°C
• IUPAC Name: [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
• InChI: InChI=1S/C35H43N7O11/c1-22(2)31(39-28(43)8-4-3-5-20-40-29(44)17-18-30(40)45)33(47)41(27(32(36)46)7-6-19-38-34(37)48)24-11-9-23(10-12-24)21-52-35(49)53-26-15-13-25(14-16-26)42(50)51/h9-18,22,27,31H,3-8,19-21H2,1-2H3,(H2,36,46)(H,39,43)(H3,37,38,48)/t27-,31
• InChIKey: UQRQGHMQKAXOTE-DHIFEGFHSA-N
• SMILES: O=C([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O)NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O

Mc-Val-Cit-PABC-PNP(CAT: I002028) is a linker commonly used in the development of antibody-drug conjugates (ADCs). It incorporates a maleimidocaproyl (Mc) group for site-specific conjugation to antibodies, a valine-citrulline (Val-Cit) dipeptide for enzymatic cleavage in the tumor microenvironment, and a para-aminobenzyloxycarbonyl (PABC) spacer to ensure efficient drug release. The p-nitrophenyl (PNP) group serves as a leaving group during synthesis. This cleavable linker system ensures selective release of the cytotoxic payload within target cells, minimizing off-target effects. Mc-Val-Cit-PABC-PNP is a valuable tool in oncology research, supporting the design and optimization of ADCs for targeted cancer therapy. Its precise cleavage properties and compatibility with diverse payloads make it a cornerstone in ADC development.