MC180295

• CAT Number: I019571
• CAS Number: 2237942-08-2
• Molecular Formula: C₁₇H₁₈N₄O₃S
• Molecular Weight: 358.41
• Purity: ≥95%
• Target: CDK
• Storage: Store at -20°C
• IUPAC Name: [4-amino-2-[[(1S,2S,4R)-2-bicyclo[2.2.1]heptanyl]amino]-1,3-thiazol-5-yl]-(2-nitrophenyl)methanone
• InChI: InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9-,10+,12+/m1/s1
• InChIKey: JRNXAQINDCOHGS-SCVCMEIPSA-N
• SMILES: C1C[C@H]2C[C@@H]1C[C@@H]2NC3=NC(=C(S3)C(=O)C4=CC=CC=C4[N+](=O)[O-])N

MC180295（Cat No.:I019571）is a selective inhibitor of soluble epoxide hydrolase (sEH), an enzyme involved in the metabolism of epoxyeicosatrienoic acids (EETs). By inhibiting sEH, MC180295 increases EET levels, which are known to have anti-inflammatory, vasodilatory, and cardioprotective effects. This makes MC180295 a valuable tool in cardiovascular and inflammation-related research, particularly for studying the role of EETs in hypertension, vascular function, and inflammation. Its specificity and potency provide a reliable option for researchers exploring therapeutic strategies targeting sEH for the treatment of cardiovascular diseases.

Reference

[1]. Zhang H, et al. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. Cell. 2018 Nov 15;175(5):1244-1258.e26.