MC4171

• CAT Number: I047715
• CAS Number: 3034769-78-0
• Molecular Formula: C21H15N3O3
• Molecular Weight: 357.37
• Purity: ≥95%
• IUPAC Name: 4-[(4Z)-5-oxo-3-phenyl-4-(1H-pyrrol-2-ylmethylidene)pyrazol-1-yl]benzoic acid
• InChI: InChI=1S/C21H15N3O3/c25-20-18(13-16-7-4-12-22-16)19(14-5-2-1-3-6-14)23-24(20)17-10-8-15(9-11-17)21(26)27/h1-13,22H,(H,26,27)/b18-13-
• SMILES: C1=CC=C(C=C1)C\2=NN(C(=O)/C2=C\C3=CC=CN3)C4=CC=C(C=C4)C(=O)O

MC4171 is a first-in-class potent and selective inhibitor of the lysine acetyltransferase KAT8 with an IC50 value of 8.1 μM. Moreover, MC4171 exhibited mid-micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, without impacting the viability of nontransformed cells. KEYWORDS: MC4171 | Supplier | KAT8 inhibitor | MC 4171 | MC-4171 | CAS [3034769-78-0] | Histone | HAT | Inhibitor | Enzymes | MOF | MYST1 | Cancer

Reference

F Fiorentino et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616.