For research use only. Not for therapeutic Use.
MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice[1].
| Catalog Number | I040533 |
| CAS Number | 1625629-51-7 |
| Synonyms | methyl (2E,4E,6E)-2-cyano-7-[4-(dimethylamino)phenyl]hepta-2,4,6-trienoate |
| Molecular Formula | C17H18N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18N2O2/c1-19(2)16-11-9-14(10-12-16)7-5-4-6-8-15(13-18)17(20)21-3/h4-12H,1-3H3/b6-4+,7-5+,15-8+ |
| InChIKey | VUICGFIMDGFKFH-FDCSDAKWSA-N |
| SMILES | CN(C)C1=CC=C(C=C1)C=CC=CC=C(C#N)C(=O)OC |
| Reference | [1]. Fu H, et al. Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting probes. Chem Commun (Camb). 2014 Oct 14;50(80):11875-8. |
