For research use only. Not for therapeutic Use.
MCC950 is a potent, selective NLRP3 inhibitor with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
| Catalog Number | I013853 |
| CAS Number | 210826-40-7 |
| Molecular Formula | C₂₀H₂₄N₂O₅S |
| Purity | ≥95% |
| Target | NOD-like Receptor (NLR) |
| Solubility | DMSO: ≥ 28 mg/mL |
| IUPAC Name | 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea |
| InChI | InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23) |
| InChIKey | HUUSXLKCTQDPGL-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O |
| Reference | [1]. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55.<br>[2]. Gan W, et al. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. Biochim Biophys Acta. 2017 Oct 3;1864(1):1-10.<br>[3]. Zhang XY, et al. Propofol Does Not Reduce Pyroptosis of Enterocytes and Intestinal Epithelial Injury After Lipopolysaccharide Challenge. Dig Dis Sci. 2018 Jan;63(1):81-91.<br>[4]. Qi Y, et al. NLRP3-dependent synaptic plasticity deficit in an Alzheimer//’s disease amyloidosis model in vivo. Neurobiol Dis. 2018 Feb 23;114:24-30. |
