MCC950

• CAT Number: I013853
• CAS Number: 210826-40-7
• Molecular Formula: C₂₀H₂₄N₂O₅S
• Molecular Weight: 404.48
• Purity: ≥95%
• Target: NOD-like Receptor (NLR)
• Solubility: DMSO: ≥ 28 mg/mL
• IUPAC Name: 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-hydroxypropan-2-yl)furan-2-yl]sulfonylurea
• InChI: InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23)
• InChIKey: HUUSXLKCTQDPGL-UHFFFAOYSA-N
• SMILES: CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O

CC950(CAT: I013853) is a highly potent and selective NLRP3 inflammasome inhibitor with an IC₅₀ of 7.5 nM in bone marrow-derived macrophages (BMDMs) and 8.1 nM in human monocyte-derived macrophages (HMDMs). By targeting the NLRP3 inflammasome, CC950 effectively blocks the activation of caspase-1 and the subsequent release of pro-inflammatory cytokines like IL-1β and IL-18, which are key mediators in inflammatory responses. CC950 shows significant potential in immunology and inflammation research, offering promising therapeutic applications for treating autoimmune diseases, neuroinflammatory disorders, and conditions like atherosclerosis and NASH where NLRP3-driven inflammation is implicated.