For research use only. Not for therapeutic Use.
MCC950 sodium(CAT: I006217), also known as CP-456773 sodium, is a small molecule inhibitor of the NLRP3 inflammasome, which is a complex involved in the activation of inflammatory responses in the body. MCC950 sodium has been shown to have therapeutic potential in the treatment of various inflammatory diseases, including rheumatoid arthritis, gout, and Alzheimer’s disease. It works by blocking the activity of NLRP3 inflammasome, thereby reducing the production of inflammatory cytokines. MCC950 sodium has been studied in several preclinical and clinical trials and has shown promising results in reducing inflammation and improving symptoms in animal models of various inflammatory diseases. It is important to note that MCC950 sodium is intended for research purposes only and should not be used for any other purposes.
| Catalog Number | I006217 |
| CAS Number | 256373-96-3 |
| Synonyms | MCC950; MCC 950; MCC-950; CP-45677; CP45677; CP 45677; CRID-3; CRID3; CRID 3; CP-456773 sodium salt; Cytokine release inhibitory drug 3.;sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide |
| Molecular Formula | C₂₀H₂₃N₂NaO₅S |
| Purity | ≥95% |
| Target | NOD-like Receptor (NLR) |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| Related CAS | 210826-40-7 |
| IC50 | 7.5 nM |
| InChI | InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1 |
| InChIKey | LFQQNXFKPNZRFT-UHFFFAOYSA-M |
| SMILES | CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+] |
| Reference | <br /> |
