MCI-INI-3

• CAT Number: I047703
• CAS Number: 1011366-31-6
• Molecular Formula: C21H15N3O4
• Molecular Weight: 373.36
• Purity: ≥95%
• IUPAC Name: methyl 5-(1,3-benzodioxol-5-yl)-2-phenylpyrazolo[1,5-a]pyrimidine-7-carboxylate
• InChI: InChI=1S/C21H15N3O4/c1-26-21(25)17-10-15(14-7-8-18-19(9-14)28-12-27-18)22-20-11-16(23-24(17)20)13-5-3-2-4-6-13/h2-11H,12H2,1H3
• SMILES: COC(=O)C1=CC(=NC2=CC(=NN12)C3=CC=CC=C3)C4=CC5=C(C=C4)OCO5

MCI-INI-3 is a potent and selective inhibitor of ALDH1A3 with an IC50 value of 0.46 μM and a Ki value of 0.55 μM. Moreover, MCI-INI-3 showed greater than 140-fold selectivity for ALDH1A3 as compared to the closely related isoform ALDH1A1.
Keywords: MCI-INI-3 | Supplier | ALDH1A3 inhibitor | ZINC20606903 | MCI-INI3 | MCI-INI 3 | ZINC 20606903 | ZINC-20606903 | MCI-INI-A3 | CAS [1011366-31-6] | Alcohol | ALDH | Inhibitor | Enzymes | MCI-INI-A3 | Mesenchymal glioma stem cells

Reference

J Li et al. A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells. Commun Biol. 2021 Dec 21;4(1):1420.