For research use only. Not for therapeutic Use.
Mcl-1 inhibitor 17 (Cat No.: I040172) is a small-molecule compound designed to selectively inhibit Mcl-1 (myeloid cell leukemia-1), a member of the Bcl-2 family of anti-apoptotic proteins. Mcl-1 plays a critical role in preventing cell death, making it a key target in cancer therapy, especially in tumors that overexpress Mcl-1 for survival. Inhibiting Mcl-1 can promote apoptosis in cancer cells, particularly in hematologic malignancies and solid tumors. Mcl-1 inhibitor 17 is being explored for its potential in overcoming drug resistance and enhancing cancer treatment efficacy.
| CAS Number | 892250-00-9 |
| Synonyms | [4-(4-fluorophenyl)piperazin-1-yl]-[1-(4-methoxyanilino)isoquinolin-4-yl]methanone |
| Molecular Formula | C27H25FN4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H25FN4O2/c1-34-22-12-8-20(9-13-22)30-26-24-5-3-2-4-23(24)25(18-29-26)27(33)32-16-14-31(15-17-32)21-10-6-19(28)7-11-21/h2-13,18H,14-17H2,1H3,(H,29,30) |
| InChIKey | JEGDKRQQLMZELX-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)NC2=NC=C(C3=CC=CC=C32)C(=O)N4CCN(CC4)C5=CC=C(C=C5)F |
| Reference | [1]. Zaneta Nikolovska-Coleska, et al. Small molecule inhibitors of mcl-1 and uses thereof. Patent. WO2015153959A2. |
